HLA-G

  • Official Full Name

    major histocompatibility complex, class I, G

  • Overview

    HLA-G is a nonclassical MHC class I (MHC-Ib) molecule structurally related to MHC class Ia (HLA-A,B, C). There are seven isoforms of this molecule, including membrane bound HLA-G1, -G2, -G3 and -G4 and soluble HLA-G5, -G6, and -G7. HLA-G is primarily expr

  • Synonyms

    HLA-G;major histocompatibility complex, class I, G;HLA G histocompatibility antigen, class I, G;HLA class I histocompatibility antigen, alpha chain G;b2 microglobulin;HLA G antigen;HLA class I molecule;MHC class I antigen G;HLA-G histocompatibility antigen, class I, G;MHC-G

Recombinant Proteins

  • Human
  • Cynomolgus
  • Rhesus macaque
  • HEK293
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • Insect cells
  • Yeast
  • In Vitro Cell Free System
  • Avi
  • His
  • B2M
  • GST
  • DDK
  • Myc
  • SUMO
  • Non
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-G-312H Recombinant Human HLA-G Protein, His-Avi-tagged HEK293 Human Avi&His It contains Gly25-Thr305 (HLA-G), Ile21-Met119 (B2M) and RIIPRHLQL peptide.
HLA-G-4305H Recombinant Human HLA-G protein, His-B2M-tagged E.coli Human B2M&His 25-308aa
HLA-G-1241H Recombinant Human HLA-G Protein HEK293 Human His 25-338 a.a.
HLA-G-13828H Recombinant Human HLA-G, GST-tagged E.coli Human GST 26-308a.a.
HLA-G-27H Recombinant Human HLA-G protein, GST-tagged Wheat Germ Human GST 1-338 a.a.
HLA-G-001H Active Recombinant Human HLA-G Protein, Myc/DDK-tagged HEK293 Human DDK&Myc
HLA-G-033H Recombinant Human HLA-G Protein, His-tagged E.coli Human His 26-308 aa
HLA-G-39H Recombinant Human HLA-G protein E.coli Human His&SUMO 25-338 a.a.
HLA-G-501H Active Recombinant Human HLA-G protein, His-Avi-tagged HEK293 Human Avi&His It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
HLA-G-505HP Active Recombinant Human HLA-G complex Protein (tetramer), His-Avi-tagged, PE-Labeled HEK293 Human Avi&His Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide
HLA-G-26H Recombinant Human HLA-G protein, MYC/DDK-tagged HEK293 Human DDK&Myc
HLA-G-38H Recombinant Human HLA-G protein E.coli Human His 25-338 a.a.
HLA-G-5493HCL Recombinant Human HLA 293 Cell Lysate HEK293 Human Non
HLA-G-1077H Recombinant Human HLA-G Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
HLA-G-1077H-B Recombinant Human HLA-G Protein Pre-coupled Magnetic Beads HEK293 Human
HLA-G-1242H Recombinant Human HLA-G & B2M Protein, His-tagged HEK293 Human His
HLA-G-1718HFL Recombinant Full Length Human HLA-G Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
HLA-G-2243H Recombinant Human HLA-G Protein, His-tagged E.coli Human His Gly25-Ile308
HLA-G-2792HFL Recombinant Full Length Human HLA-G protein, Flag-tagged Mammalian Cells Human Flag Full L.
HLA-G-3036H Recombinant Human HLA-G protein, His-SUMO-tagged E.coli Human His&SUMO 25-308aa
HLA-G-3075H Recombinant Human HLA-G Protein (Met29-His117), N-GST tagged E.coli Human GST Met29-His117
HLA-G-3322H Recombinant Human HLA-G protein, His-tagged Insect cells Human His 25-319aa
HLA-G-502H Recombinant Human HLA-G protein(Gly25-Thr305(C66S)), His-Avi-tagged E.coli Human Avi&His Gly25-Thr305(C66S)
HLA-G-503C Recombinant Cynomolgus HLA-G protein, His-Avi-tagged HEK293 Cynomolgus Avi&His Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide
HLA-G-503CB Recombinant Cynomolgus HLA-G protein, His-Avi-tagged, Biotinylated HEK293 Cynomolgus Avi&His Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide
HLA-G-503H Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
HLA-G-504H Recombinant Human HLA-G protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
HLA-G-505C Recombinant Cynomolgus HLA-G Tetramer protein, His-Avi-tagged HEK293 Cynomolgus Avi&His Gly25-Thr305(HLA-G)&Ile21-Met119(B2M)
HLA-G-506R Recombinant Rhesus macaque HLA-G protein, His-Avi-tagged HEK293 Rhesus macaque Avi&His It contains Gly25-Thr305(HLA-G),Ile21-Met119(B2M) and RIIPRHLQL peptide.
HLA-G-5426H Recombinant Human HLA-G protein Yeast Human His&SUMO 25-338 a.a.
HLA-G-651HF Recombinant Full Length Human HLA-G Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 338 amino acids

    Involved Pathway

    HLA-G involved in several pathways and played different roles in them. We selected most pathways HLA-G participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ne thyroid disease Ifna11,HLA-DQA2,TPO,HLA-DRB4,HLA-DQA1,H2-AB1,HLA-DOB,FAS,HLA-DRA,HLA-DRB3
    Viral myocarditis HLA-DPB1,Casp3,ABL2,HLA-DQA2,EIF4G3,HLA-DPA1,HLA-DMB,ICAM1,HLA-DQB1,HLA-DMA
    Antigen processing and presentation LGMN,H2-AB1,HSPA8,HLA-DPA1,HLA-DRB4,KIR2DS4,HLA-DRB5,PSME1,HLA-DPB1,TAP2
    Endocytosis ARF1L,WASH,VPS37C,ASAP1,PARD6GA,ARAP3,KITA,CHMP2BB,HSPA6,EHD3
    Type I diabetes mellitus GAD2,HLA-DRB4,HLA-DPA1,HLA-DPB1,HLA-DRA,PTPRN2,HLA-F,HLA-DQA1,CD28,HSPD1
    Graft-versus-host disease PRF1,HLA-B,HLA-F,H2-Q10,KIR2DL1,HLA-DQA1,HLA-C,HLA-DRB1,IL1B,HLA-DRA
    Natural killer cell mediated cytotoxicity ULBP3,ZAP70,IFNA2,BID,KLRC4-KLRK1,Raet1c,NCR3,FYN,TNF,RAET1D
    Allograft rejection IFNG,HLA-DRB5,IL12A,H2-AA,FASLG,IL12B,HLA-DOA,MICA,IL10,IL5
    Cell adhesion molecules (CAMs) NEO1A,OCLNA,PVRL3B,CLDNJ,CLDN5,CLDN7A,ALCAM,HLA-DOB,H2-AB1,CD99

    Protein Function

    HLA-G has several biochemical functions, for example, peptide antigen binding,protein homodimerization activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-G itself. We selected most functions HLA-G had, and list some proteins which have the same functions with HLA-G. You can find most of the proteins on our site.

    Function Related Protein
    receptor binding BMP3,Fgf15,WNT2BA,AKAP9,PLAUR,TGFB2,RSPO3,PVRL3B,GSTM7,LGI1
    protein homodimerization activity SLC24A6,UGT1A2,TIMM9,CEACAM5,ERCC5,CADM2A,HM13,BAXB,RQCD1,GPD1
    peptide antigen binding MHC1UIA,HLA-DPB1,H2-AA,CD209,HLA-DQA1,MHC1UEA,HLA-E,MHC1ZDA,H2-Q10,MHC1UKA

    Interacting Protein

    HLA-G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-G here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-G.

    LILRB1;HLA-A

    Resources

    Gene Families

    What is immunoglobulin superfamily (IgSF)

    Research Area

    T Cell Antigen Recognition

    References

    • Han, MY; Jiang, YZ; et al. sHLA-G Involved in the Apoptosis of Decidual Natural Killer Cells Following Toxoplasma gondii Infection. INFLAMMATION 37:1718-1727(2014).
    • Brugiere, O; Thabut, G; et al. Role of HLA-G as a Predictive Marker of Low Risk of Chronic Rejection in Lung Transplant Recipients: A Clinical Prospective Study. AMERICAN JOURNAL OF TRANSPLANTATION 15:461-471(2015).

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